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Answer:Both pseudoephedrine and phenylephrine are decongestants used to treat nasal congestion due to allergies, colds, sinus infections, etc. Since pseudoephedrine can be made into methamphetamine, the U.S. Senate passed a bill restricting its sale. Products containing phenylephrine can not be made into methamphetamine, so their sale is not restricted.

Unfortunately, no studies have been done to confirm whether these two decongestants are equally effective. There are some differences in the way the drugs are absorbed by the body:

Since people will react differently to each medication, it is difficult to say whether they are equally effective. If you are considering trying either medication, discuss it with your doctor or pharmacist first. People with certain medical conditions such as diabetes, heart disease, high blood pressure, and overactive thyroid should not take products containing either of these ingredients. Also, people taking propranolol or certain antidepressants should avoid using these products.

Learn more about drug interactions.

Visit our Allergy Center.

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